| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
|
| País: |
Brazil
|
| Título: |
Hereditary cancer risk assessment: insights and perspectives for the Next-Generation Sequencing era
|
| Autores: |
Gomy,Israel
Diz,Maria Del Pilar Estevez
|
| Data: |
2016-06-01
|
| Ano: |
2016
|
| Palavras-chave: |
Next-generation sequencing
Hereditary cancer
Genetic counseling
Risk assessment
|
| Resumo: |
Abstract Hereditary cancer risk assessment is a multidisciplinary and dynamic process, with the purpose of estimating probabilities of germline mutations in cancer susceptibility genes and assessing empiric risks of cancer based on personal and family histories, in order to offer clinical and molecular diagnoses and clinical management based on these risks. Genetic tests are available and most of them are reimbursed by insurance companies, although they are generally not covered by the public health systems of developing countries. More recently, molecular diagnosis of hereditary cancer is feasible through next-generation sequencing (NGS) panels. Here we review the benefits and limitations of NGS technologies in the clinical practice.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000200184
|
| Editor: |
Sociedade Brasileira de Genética
|
| Relação: |
10.1590/1678-4685-gmb-2014-0346
|
| Formato: |
text/html
|
| Fonte: |
Genetics and Molecular Biology v.39 n.2 2016
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
